---
name: Cassia, LLC
slug: cassiallc
site: cro
website_domain: cassiallc.com
summary: Cassia, LLC is a San Diego-based CRO specializing in green chemo-enzymatic synthesis of stable-isotope labeled metabolites, proteins, and nucleic acids, plus LC-MS/MS RNA modification mapping services for discovery and therapeutic development. Headquartered in San Diego, United States.
tagline: Green chemo-enzymatic synthesis and RNA modification analysis for discovery and therapeutic development.
founded_year: 2004
employee_count_band: 
employee_count_label: 
parent_name: 
parent_slug: 
hq_country: US
tier2_domain_verified: false
updated_at: 2026-09-21T07:03:31.109Z
services_count: 4
modalities_count: 2
indications_count: 3
locations_count: 1
review_signal_gate: closed
generated_by: BioBM Editorial AI
---

# Cassia, LLC

Green chemo-enzymatic synthesis and RNA modification analysis for discovery and therapeutic development.

Listed on cro.directory.

## Summary

Cassia, LLC is a San Diego-based CRO specializing in green chemo-enzymatic synthesis of stable-isotope labeled metabolites, proteins, and nucleic acids, plus LC-MS/MS RNA modification mapping services for discovery and therapeutic development. Headquartered in San Diego, United States.

## At a glance

- Founded: 2004
- HQ country: US

## Services

- Translational Research
- Analytical Method Development & Validation
- Bioanalysis
- LC-MS Bioanalysis (Small Molecule)

## Modalities

- Oligonucleotide
- mRNA

## Indications

- Oncology
- Neurology
- Rare Disease

## Locations

- Headquarters, San Diego, California, United States

## Long description

## Overview

Cassia, LLC is a privately held Contract Research Organization (CRO) founded in 2004 and headquartered in San Diego, California. The company specializes in biocatalysis-based synthesis solutions and analytical services for pharmaceutical, biotechnology, and research organizations.

## Core Capabilities

**Chemo-Enzymatic Synthesis**
- Green, environmentally friendly synthesis of stable-isotope labeled compounds
- Primary and secondary metabolites, proteins, nucleic acids, and analogs
- Biocatalytic routes optimized through enzyme engineering and site-directed mutagenesis
- Custom biotechnology solutions with FTE (Full-Time Equivalent) outsourcing agreements

**RNA Modification Analysis**
- LC-MS and LC-MS/MS–based RNA modification profiling
- Validated workflows for sensitive, precise, quantitative detection of nucleoside modifications
- Coverage of mRNA, rRNA, tRNA, and custom-synthesized RNA (60–80% coverage)
- Customizable panels spanning methylation, acetylation, prenylation, pseudouridylation, and related modifications
- Applications in discovery, translational research, and therapeutic development

**Research Services**
- Assay development
- Metabolic research
- EPR, MS, NMR analysis
- Molecular biology and organic synthesis
- Protein and nucleic acid production

## Differentiation

Cassia leverages enzyme and metabolic engineering to recapitulate biosynthetic pathways in vitro, enabling cost-effective manufacturing scale-up and novel solutions to overcome existing manufacturing difficulties. The company maintains strict confidentiality agreements and offers flexible, collaborative service models tailored to client objectives.

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_Profile last updated: 2026-09-21T07:03:31.109Z. Profile facts may include AI-assisted enrichment._

Auto-generated by BioBM Editorial AI for machine-readable profile access.