ChemDiv

Overview

ChemDiv is a fully integrated target-to-clinic contract research organization (CRO) headquartered in San Diego, CA. Over 32 years, the company has successfully completed hundreds of leads, drug candidates, and new drug programs for pharma, biotech, and academic partners globally.

Core Capabilities

Discovery & Chemistry Services:

• Integrated drug discovery from target identification through lead optimization
• Medicinal chemistry and custom synthesis with FTE engagement
• In silico drug design (CADD) and computational chemistry
• Discovery biology and functional assays
• ADME and DMPK services
• Toxicology and safety assessment with GLP and CMP compliance
• Animal models and in vivo/in vitro pharmacology

Compound Libraries & Screening:

• 1.6 million stock-available compounds
• 12 million managed global inventory
• 2 trillion synthetically feasible chemistry structures
• 114 predesigned focused and targeted screening libraries
• 17 annotated active reference sets with >220,000 compounds and >25,000 targets
• Diversity libraries (2D and 3D)
• Preplated libraries covering 30B virtual space
• Building blocks, inhibitors, approved drugs, and natural product-based compounds

Technology Platforms:

• Hybrid AI/Machine Learning (ML) curated by scientists at each discovery step
• Proprietary platforms: molecular glues, stabilizers, degraders, covalent and non-covalent binders, bifunctional molecules, new-generation ADCs, RNA and DNA editing
• Adds ~50,000 novel diverse and targeted compounds annually

Therapeutic Areas

Cancer, CNS/neurological, infectious disease, cardiometabolic, immunology, inflammation, and virology.

Track Record

• 47 approved drugs developed with ChemDiv support
• 2,700+ satisfied customers
• 5 R&D hubs worldwide
• 30+ years of industrial experience
• Delivery of validated clinical assets in as little as 18 months

Regulatory & Compliance

Services include CMC (Chemistry, Manufacturing, and Controls), GLP toxicology, and regulatory support.