---
name: Tioga Research
slug: tiogaresearch
site: cro
website_domain: tiogaresearch.com
summary: Tioga Research specializes in topical and transdermal formulation development and testing, offering proprietary Cascade Screening™ methodology, high-throughput experimentation platforms, and in vitro skin permeation testing for pharmaceutical and cosmetic clients. Headquartered in San Diego, United States.
tagline: Topical formulation development with proprietary Cascade Screening™ and high-throughput experimentation platforms.
founded_year: 
employee_count_band: 
employee_count_label: 
parent_name: 
parent_slug: 
hq_country: US
tier2_domain_verified: false
updated_at: 2026-10-12T07:02:59.292Z
services_count: 2
modalities_count: 1
indications_count: 0
locations_count: 1
review_signal_gate: closed
generated_by: BioBM Editorial AI
---

# Tioga Research

Topical formulation development with proprietary Cascade Screening™ and high-throughput experimentation platforms.

Listed on cro.directory.

## Summary

Tioga Research specializes in topical and transdermal formulation development and testing, offering proprietary Cascade Screening™ methodology, high-throughput experimentation platforms, and in vitro skin permeation testing for pharmaceutical and cosmetic clients. Headquartered in San Diego, United States.

## At a glance

- HQ country: US

## Services

- Analytical Method Development & Validation
- ICH Stability Studies

## Modalities

- Small Molecule

## Locations

- Headquarters, San Diego, CA, USA

## Long description

## Overview

Tioga Research is a contract research organization focused on topical and transdermal formulation development and testing for pharmaceutical and prestige cosmetic companies. The organization integrates proprietary formulation development strategies, innovative high-throughput experimentation (HTE) platforms, and traditional in vitro testing methodologies.

## Core Capabilities

**Cascade Screening™ Platform**
A proprietary, multi-step molecule-topical excipient screening platform designed to reduce time-to-insight and efficiently identify high-performing formulation paths tailored to client molecules.

**High-Throughput Experimentation (HTE)**
Rapid screening of hundreds of formulation compositions to identify and select the most effective candidates for topical delivery.

**In Vitro Testing**
- In Vitro Release Testing (IVRT)
- In Vitro Permeation Testing (IVPT)
- Cosmetic in vitro testing services

**Formulation Development**
Comprehensive formulation optimization services coupled with in silico screening of compound libraries.

**Manufacturing Services**
Clinical and commercial manufacturing capabilities for topical formulations.

## Regulatory Track Record

Tioga's scientific team pioneered the development methodology instrumental in the successful FDA approval and commercialization of Pennsaid® 2% (diclofenac sodium topical solution), a higher-strength prescription product for osteoarthritis of the knee. The team applied rigorous scientific methodology through Cascade Screening™ and advanced in vitro skin permeation testing to enhance drug delivery while maintaining pharmaceutical stability and meeting regulatory requirements. Pennsaid® 2% has achieved approximately $6 billion in cumulative sales.

## Related companies

- [CAL Laboratories](/companies/cal-laboratories) (Analytical Method Development & Validation, ICH Stability Studies) — [Compare](/compare/cal-laboratories/tiogaresearch)
- [Pace Analytical](/companies/pacelabs) (Analytical Method Development & Validation, ICH Stability Studies) — [Compare](/compare/pacelabs/tiogaresearch)
- [AMSbiopharma](/companies/amsbiopharma) (Analytical Method Development & Validation, ICH Stability Studies) — [Compare](/compare/amsbiopharma/tiogaresearch)
- [Eurofins Canada](/companies/eurofins-canada) (Analytical Method Development & Validation, ICH Stability Studies) — [Compare](/compare/eurofins-canada/tiogaresearch)
- [Microbac Laboratories](/companies/microbac) (Analytical Method Development & Validation, ICH Stability Studies) — [Compare](/compare/microbac/tiogaresearch)
- [Intrepid Labs](/companies/intrepid-labs) (Analytical Method Development & Validation) — [Compare](/compare/intrepid-labs/tiogaresearch)
- [Emery Pharma](/companies/emerypharma) (Analytical Method Development & Validation, ICH Stability Studies) — [Compare](/compare/emerypharma/tiogaresearch)
- [BioQual Solutions Inc.](/companies/bioqualsolutions) (Analytical Method Development & Validation, Small Molecule) — [Compare](/compare/bioqualsolutions/tiogaresearch)

_Profile last updated: 2026-10-12T07:02:59.292Z. Profile facts may include AI-assisted enrichment._

Auto-generated by BioBM Editorial AI for machine-readable profile access.