CanAm Bioresearch Inc.

Overview

CanAm Bioresearch is a medicinal chemistry contract research organization specializing in accelerating drug discovery through custom chemistry and analytical services. The company operates as an extension of client chemistry teams, leveraging an all-Ph.D. scientific staff and 25+ years of industry experience.

Core Services

Drug Discovery & Medicinal Chemistry

• Custom organic synthesis tailored to project-specific drug discovery goals
• Structure-activity relationship (SAR) support with rapid compound redesign based on biological assay feedback
• Demonstrated capability to advance projects from initial hits to viable drug candidates

Analytical Chemistry & Bioanalysis

• HPLC-UV and LC-MS analysis
• Chemical purity determination and certificates of analysis
• Synthetic impurity identification and structure elucidation
• Solubility testing in solvents, buffers, and vehicles
• Stability studies (pH, thermal, photochemical)
• Pharmacokinetics profiling using LC-MS/MS (rat, mouse, dog bioavailability; mouse PK with up to 10 time points per animal)
• Plasma and blood level analysis from tissue distribution studies
• First-line ADME analyses and metabolite structure elucidation via multinuclear NMR
• Non-GLP analytical work with rapid turnaround (PK results within days)

Biological Services

• Biochemical assays (ELISA) for compound-target interaction determination
• Metabolic stability testing using animal or human liver microsomes
• Coordination of in-vivo animal testing for pharmacokinetics and distribution studies
• Integrated biological activity assessment of synthesized compounds

Differentiation

The company emphasizes fast-paced discovery support, combining synthetic chemistry expertise with robust analytical and bioanalytical capabilities. Client testimonials highlight reliable compound delivery, efficient re-design cycles, and the ability to advance projects rapidly (e.g., from initial hits to viable drug candidate within 500 total compounds over 3 years).