Cassia, LLC

Overview

Cassia, LLC is a privately held Contract Research Organization (CRO) founded in 2004 and headquartered in San Diego, California. The company specializes in biocatalysis-based synthesis solutions and analytical services for pharmaceutical, biotechnology, and research organizations.

Core Capabilities

Chemo-Enzymatic Synthesis

• Green, environmentally friendly synthesis of stable-isotope labeled compounds
• Primary and secondary metabolites, proteins, nucleic acids, and analogs
• Biocatalytic routes optimized through enzyme engineering and site-directed mutagenesis
• Custom biotechnology solutions with FTE (Full-Time Equivalent) outsourcing agreements

RNA Modification Analysis

• LC-MS and LC-MS/MS–based RNA modification profiling
• Validated workflows for sensitive, precise, quantitative detection of nucleoside modifications
• Coverage of mRNA, rRNA, tRNA, and custom-synthesized RNA (60–80% coverage)
• Customizable panels spanning methylation, acetylation, prenylation, pseudouridylation, and related modifications
• Applications in discovery, translational research, and therapeutic development

Research Services

• Assay development
• Metabolic research
• EPR, MS, NMR analysis
• Molecular biology and organic synthesis
• Protein and nucleic acid production

Differentiation

Cassia leverages enzyme and metabolic engineering to recapitulate biosynthetic pathways in vitro, enabling cost-effective manufacturing scale-up and novel solutions to overcome existing manufacturing difficulties. The company maintains strict confidentiality agreements and offers flexible, collaborative service models tailored to client objectives.