Cassia, LLC

Overview

Cassia, LLC is a privately held Contract Research Organization (CRO) founded in 2004 and headquartered in San Diego, California. The company specializes in biocatalytic and green chemistry solutions for the synthesis of stable-isotope labeled compounds and custom biotechnology services.

Core Capabilities

Biocatalytic Synthesis

• In vitro enzyme-catalyzed reactions using purified enzymes for higher substrate loading, greater yields, and cost-effective solutions
• Production of primary and secondary metabolites, as well as analogs
• Enzyme and metabolic engineering using structural data, mutant libraries, and site-directed mutagenesis
• Manufacturing-scale biocatalytic routes demonstrating significant cost savings over traditional biomass manufacturing

Green Chemistry

• Environmentally friendly chemo-enzymatic synthesis processes
• Enzyme-catalyzed reactions utilizing water as solvent and ambient temperatures/pressures
• Commitment to reducing organic chemical consumption and downstream waste

Product Lines

• Stable-isotope labeled amino acids, carbohydrates, nucleosides, nucleotides, and proteins
• Custom-synthesized RNA and analogs

Analytical Services

• LC-MS and LC-MS/MS–based RNA modification profiling with 60–80% RNA coverage
• Validated workflows for sensitive, precise, and quantitative detection of nucleoside modifications (methylation, acetylation, prenylation, pseudouridylation, and more)
• Support for discovery, translational research, and therapeutic development
• Applications in oncology, neurological disease, mitochondrial disorders, and RNA-targeted therapeutics

Contract Research & Development

• Full-Time Equivalent (FTE) agreements with fixed-rate project teams or exclusive product dedication
• Contractual guarantees of non-conflict with existing client projects
• Applications in EPR, MS, NMR, assay development, and metabolic research

Facilities & Infrastructure

Located in Sorrento Mesa Business Center (Mira Mesa region, San Diego), occupying approximately 1,580 sq. ft. equipped for basic and applied research in molecular biology, biocatalysis, organic synthesis, and protein/nucleic acid production.

Service Model

Serves nationwide and select international clients with a focus on maintaining highest standards in research and service, proven track record in nucleic acids and protein chemistry, and rapid response to new technologies.