Crown Bioscience

Crown Bioscience is a global drug discovery and development service company specializing in translational oncology and metabolic disease research. The company maintains the world's largest PDX (patient-derived xenograft) model collection with 2,500+ global models, complemented by 600+ organoid models, 1,000+ cancer cell lines, and 200+ CDX (cell line-derived xenograft) models. Crown Bioscience's model databases are accessible through OncoExpress, a data platform enabling researchers to query tumor growth curves, standard-of-care responses, biomarker identification, gene expression, and mutation analysis across PDX, CDX, syngeneic, GEMM, and MuPrime models.

The company offers specialized preclinical services including patient-derived translational oncology, biomarker and bioanalysis services, clinical biomarker and biospecimen services, and bioinformatics solutions. Crown Bioscience maintains expertise in immunology research through its IO Murine Models Database, which includes syngeneic, GEMM, tumor homograft, and humanized genetically modified mouse models. The organization partners with clinical centers (e.g., NEXT Oncology) to develop clinically-relevant PDX models incorporating latest targeted therapies and immunotherapies, with particular focus on mechanisms of resistance.