PI Health Sciences

Overview

PI Health Sciences is a leading Contract Research, Development and Manufacturing Organization (CRDMO) providing integrated solutions from discovery through commercial manufacturing. A subsidiary of PI Industries (founded 1946), the organization combines 80 years of chemistry expertise with modern AI and computational capabilities.

Discovery & Development Services

• Integrated Drug Discovery (IDD): Co-located teams delivering synthetic chemistry, medicinal chemistry, biology, and preclinical toxicology with AI/computational chemistry integration
• Chemistry Services: Molecular modeling, scaffold synthesis, impurity characterization, strategic IP evaluation, and route scouting
• DMPK Services: Drug metabolism and pharmacokinetics support
• Preclinical Services: Full preclinical toxicology and safety assessment
• Process Development: Discovery process chemistry, route scouting, process development, and process safety evaluation
• Analytical Services: Method development and validation, genotoxic impurity analysis, stability and forced degradation testing, potent compound analysis, trace metal testing, salt and polymorph screening

Manufacturing & Scale-Up

• GMP/Non-GMP Scale-Up: Phase-appropriate development from preclinical through commercial scale
• Manufacturing Services: Preclinical, clinical, and commercial manufacturing capabilities
• Process Safety: Advanced safety evaluations, hazard identification and assessment, thermal stability analysis, dust explosion testing, and engineering controls implementation

Enabling Technologies

• Flow Chemistry: Integrated flow chemistry services
• Biocatalysis: Integrated biocatalysis services
• In Silico Genotoxicity: Computational genotoxicity prediction
• New Modalities: PROTAC, LYTAC, molecular glues, AUTAC, and other targeted protein degradation (TPD) platforms

Regulatory & Quality

• Global regulatory compliance expertise supporting discovery to market
• Project management with certified project managers, agile methodologies, and cloud-based collaboration
• High potency compound analysis capabilities

Global Presence

R&D and manufacturing locations in Europe (Italy) and India (Hyderabad, Panoli, Jaipur, Ankleshwar), serving big pharma and biotech partners across the US, Europe, and Japan.