NEPHRIX Biosolutions

NEPHRIX Biosolutions is a preclinical contract research organization focused exclusively on kidney and fibrotic disease research. The company provides a full range of in vitro and in vivo preclinical services including validated rodent models, human primary cell assays, and high-quality histology with quantitative digital pathology.

In Vitro Services:

• Fibrosis assays using human primary fibroblasts from renal, lung, cardiac, and skin origins
• Inflammation assays
• Senescence assay platform with human primary cells from various tissue origins
• DuoXProx renal co-culture model
• Nephrotoxicity screening on human-derived cells

In Vivo Models:

• Ischemia Reperfusion Injury (IRI) kidney model
• Unilateral Ureteral Obstruction (UUO) model
• Streptozotocin (STZ) diabetic nephropathy models in rats and mice
• IgA nephropathy model
• Adenine-induced kidney disease model
• Surgical models with validated ethical procedures on mice and rats

Additional Capabilities:

• Biomarker analysis and bioanalysis platform to assess therapeutic efficacy, safety, and mechanism of action
• Histology expertise in fibrosis, inflammation, nephrotoxicity, and aging
• Fast study initiation with adaptable study designs
• Commitment to ethical practices and 3Rs principles