Cyagen Biosciences

Overview

Cyagen Biosciences is a preclinical research CRO specializing in genetically engineered animal models, custom cell line development, and viral vector packaging. The organization operates AAALAC-accredited facilities and has delivered over 50,000 mouse and rat models to 10,700 global bioscience partners.

Core Capabilities

Genetically Engineered Animals

• Knockout, knockin, and transgenic mice and rats with high genetic precision
• HUGO-GT™ (Humanized Genomic Ortholog) platform for full-gene humanization
• HUGO-Ab™ for antibody discovery and validation
• Disease-specific models: neurological (Alzheimer's, Parkinson's, Huntington's), ophthalmic (glaucoma, AMD), metabolic (obesity, diabetes), autoimmune (SLE, RA), and oncology models
• Humanized immune system (HIS) and PBMC models
• Advanced model generation techniques: TurboKnockout™, gene targeting, Cre-ESCs, targeted gene editing, PiggyBac transgenesis, BAC transgenesis

Custom Cell Lines

• Induced pluripotent stem cells (iPSCs)
• Knockout and knockin cell lines
• Point mutation and overexpression cell lines
• Tumor cell lines and knockout cell line catalogs

Viral Packaging Services

• Adeno-associated virus (AAV) packaging with AI-powered discovery
• Lentivirus and adenovirus packaging for gene therapy and vaccine R&D applications

Supporting Services

• Breeding and cryopreservation/recovery
• Phenotyping services
• BAC modification
• Preclinical efficacy studies

Regulatory & Quality

Facilities maintain AAALAC accreditation with 250,000 SPF animals in accredited facilities, ensuring ethical research practices and animal welfare standards.